MOTS-c
What is MOTS-c?
MOTS-c or M O T S-c is a peptide. But it’s considered an MDP.
MDPs are short for Mitochondrial Derived Peptides. MDPs are found inside our Mitochondria.
I’m positive we are all familiar with DNA that is found inside our cell’s nucleus, but did you know that our mitochondria actually have their own DNA?
Our mitochondria have MITOCHONDRIAL DNA known as mtDNA, which can encode various proteins and peptides just like the DNA inside our nucleus.
MDPs are mitochondrial-derived peptides, meaning they are peptides made inside of your mitochondria using their own DNA.
I always wondered why Mitochondria had a squiggly frame in my physiology book. Like a winding lake, this provides more surface area between the inner and outer membrane, and it is via this space that energy is generated to power our mitochondria and, therefore, us.
How do Mitochondria create power?
Mitochondria are considered the Powerhouse of our cells. These are our mighty mini engines inside every cell, creating ATP. Further, every cell in your body can have between 1000 and 2500 mitochondria.
ATP cannot be stored, so Mitochondria need to be making a constant supply of ATP.
How is ATP created?
The creation of ATP begins with the Electron Transport Chain or Oxidative Phosphate.
Basically, it’s a proton pump, exchanging electrons and protons between the interior matrix and into the intermembrane.
Protons in this space need to move into the matrix but can only enter through the ATP Synthase channel. They are pushed into this channel by pressure that builds up behind the inner wall membrane, like a damn.
This creates kinetic energy, which becomes ATP, powering the mitochondria to create mitochondrial-derived peptides.
Youtube video on how this intermembrane pump works to make ATP
Inside the Mitochondria matrix, there are small open reading frames sORFs. These small circles encode functional microproteins called mitochondria-derived peptides (MDPs). These MDPs can stay inside mitochondria, enter the cytosol, translocate to the nucleus, or be secreted extracellularly to target tissues.
Now we understand that our Mitochondria make ATP, how they make energy, and that MOTSc is created by sORFs inside the matrix of the Mitochondria.
How was it discovered?
MOTS-c is one of three identified MDPs.
Humanin was the first MDP discovered.
Scientists began looking at Mitochondria for aging because of its role in cellular energy and cell signaling. This is due to the mitochondrial dysfunction observed in Alzheimer’s and Parkinson’s disease. Apparently, our brain tissue is mitochondria-rich and is highly sensitive to any mitochondrial changes.
Mitochondria dysfunction is also linked to obesity, and further Cancer is linked to mitochondrial DNA instability.
As they have identified these MDPs MOTS-c has stood out.
Reserach began on MOTS-c in 2015. These small peptides made inside our Mitochondria signal different pathways and MOTS-c is special because it has been shown to mimic exercise and prevent muscle atrophy.
How does it work?
MOTS-c stands out because it communicates between the mitochondria and the nucleus. And it is encoded with mitochondrial DNA.
Researchers have found the highest levels of MOTS-c in the young and the highest concentrations of this peptide inside skeletal muscle cells.
TRANSLOCATION
When MOTS-c moves from the mitochondria to the nucleus, it activates the AMPK pathway.
AMPK is a sensor inside the nucleus that is in charge of making sure there is enough ATP.
AMPK
Once activated, AMPK increases fatty acid oxidation. This increases fat burning and glycolysis, the breakdown of sugars.
The flow of MOTS-c into the nucleus turns on energy use.
One way to stimulate the flow of MOTS-c is with exercise, and this is why higher levels are found inside skeletal muscle cells. Muscle cells require more energy.
We want AMPK initiated because it also shuts down acetyl-CoA carboxylase. This enzyme signals our body to convert triglycerides into fatty acids and store them in our liver and fat cells.
Our entire glucose breakdown and energy production begins with MOTS-c. Because the presence of MOTS-c optimizes energy, thereby optimizing our cells for production.
It’s similar to gas for your car.
This is why AMPK-triggering drugs are considered an exercise in a pill or injection.
Metformin acts as an AMPK activator but has side effects.
MOTS-c is reported to have the following benefits:
- Increases energy burning, and lowers the pool of glucose that would normally be stored.
- When AMPK is activated by MOTS-c, it stimulates the creation and clearance of new and old mitochondria, by maintaining balance and optimizing the healthiest mitochondria.
- MOTS-c Increases NAD+ levels
- MOTS-c decreases the loss of dermal collagen.
- Improves Insulin Sensity
- Improves muscle health
Hope this helps- follow me along my journey where I dose and inject inside the Natural Kaos App, we also have a large Peptide group where we share supplies and information that helps others on their peptide journey! – KIM
NATURAL KAOS APP LINKS:
ANDROID
Comment “HAIR” for this microneedling scalp video link sent to your DM Inbox.
On Facebook? Look below for link 👇🏻
I filmed this scalp microneedling treatment in 2021. I used Stems cells and placenta to help improve hair density and growth.
Throwbacks are useful because you can also see how my face has changed over the years.
All items I used in this video will be linked in a blog post on the naturalkaos.com blog.
VIDEO LINK:
https://urlgeni.us/youtube/MicroneedlingScalp
Comment “HAIR” for this microneedling scalp video link sent to your DM Inbox.
On Facebook? Look below for link 👇🏻
I filmed this scalp microneedling treatment in 2021. I used Stems cells and placenta to help improve hair density and growth.
Throwbacks are useful because you can also see how my face has changed over the years.
All items I used in this video will be linked in a blog post on the naturalkaos.com blog.
VIDEO LINK:
https://urlgeni.us/youtube/MicroneedlingScalp
TIRZEPATIDE DEAL explained 👇🏻
“Walkie-Talkie” realities of peptides and personal goals:)
DAY 8 of 3 Mile/Day Walk Challenge
In todays, little LIVE Walk, which took 4 hrs to finally post 🤯🙈 ugh tech!
I explained about my 3 mile per day walk goal and how the time commitment for this goal is harder than I anticipated…but we are going to continue…
✅ I walk at a 5 incline at between a 3 & 3.5 mph pace.
I use a @nordictrack
I shared about the peptides I started this week. Tirzepatide and MELANOTAN 2 and my thoughts/plans with these two peptides.
We touched on skin concepts such as PLLA, PCL, TOX, & MESO.
This past Monday I injected 5ml of Mayster PDRN from my temples, to my cheeks, to above my lip. That LIVE demo is found inside the Natural Kaos App.
🎁TIRZEPATIDE DEAL!!!
We are so lucky to finally find a source and a MD who will work with the Natural Kaos App and provide our members with this amazing peptide at the best cost possible!
10MG Vial of Tirzepatide, For $160
It ships from a California doctors office anywhere in the US and worldwide.
✅ ONLY For active Natural Kaos APP Members
To learn more about this real I have a blog up on the Naturalkaos.com blog explaining more.
If you aren’t already a Natural Kaos APP member now is the time so you can be Bikini 👙 Ready for Summer 2024!!!
We are currently working on deals for additional peptides as well…standby
TIRZEPATIDE DEAL explained 👇🏻
“Walkie-Talkie” realities of peptides and personal goals:)
DAY 8 of 3 Mile/Day Walk Challenge
In todays, little LIVE Walk, which took 4 hrs to finally post 🤯🙈 ugh tech!
I explained about my 3 mile per day walk goal and how the time commitment for this goal is harder than I anticipated…but we are going to continue…
✅ I walk at a 5 incline at between a 3 & 3.5 mph pace.
I use a @nordictrack
I shared about the peptides I started this week. Tirzepatide and MELANOTAN 2 and my thoughts/plans with these two peptides.
We touched on skin concepts such as PLLA, PCL, TOX, & MESO.
This past Monday I injected 5ml of Mayster PDRN from my temples, to my cheeks, to above my lip. That LIVE demo is found inside the Natural Kaos App.
🎁TIRZEPATIDE DEAL!!!
We are so lucky to finally find a source and a MD who will work with the Natural Kaos App and provide our members with this amazing peptide at the best cost possible!
10MG Vial of Tirzepatide, For $160
It ships from a California doctors office anywhere in the US and worldwide.
✅ ONLY For active Natural Kaos APP Members
To learn more about this real I have a blog up on the Naturalkaos.com blog explaining more.
If you aren’t already a Natural Kaos APP member now is the time so you can be Bikini 👙 Ready for Summer 2024!!!
We are currently working on deals for additional peptides as well…standby
Where to BUY Tirzepatide??? Comment “DEAL”
This has been a question I’ve fielded all 2024.
I’m happy to share that we have secured a special deal for our Natural Kaos App members.
$160 for 10mg of Tirzepatide issued by an MD.
Shipped from California to all US + Worldwide.
This deal is available to our Natural Kaos App members.
Our app is found on both Apple and Android.
Comment “DEAL” in the comments and I’ll send you the link to our app and to the Tirzepatide Blog about this deal.
Everyone is going to bikini ready this summer with this deal!!!
#weightlosstransformation
Where to BUY Tirzepatide??? Comment “DEAL”
This has been a question I’ve fielded all 2024.
I’m happy to share that we have secured a special deal for our Natural Kaos App members.
$160 for 10mg of Tirzepatide issued by an MD.
Shipped from California to all US + Worldwide.
This deal is available to our Natural Kaos App members.
Our app is found on both Apple and Android.
Comment “DEAL” in the comments and I’ll send you the link to our app and to the Tirzepatide Blog about this deal.
Everyone is going to bikini ready this summer with this deal!!!
#weightlosstransformation
MESO MONDAY:)
Today inside the Natural Kaos App I will be reconstituting two Peptides:
-Melanitan 2
-Tirzepatide (not for weightloss, I’m microdosing)
Next…
I will mix up the Mayster PDRN and place it in my face.
PDRN BENEFITS:
PDRN molecules are able to stimulate the metabolic activity of cells in your skin to regenerate collagen.
It can also stimulate wound recovery through boosting the rate of growth of fibroblasts, the cells mainly responsible for collagen production.
The activator in this set has glutathione which will brighten my skin as new tissue is encouraged to grow.
SCHEDULE:
-3PM PST TIKTOK LIVE PREP (numb up)
-4PM PST APP LIVE (application)
MESO MONDAY:)
Today inside the Natural Kaos App I will be reconstituting two Peptides:
-Melanitan 2
-Tirzepatide (not for weightloss, I’m microdosing)
Next…
I will mix up the Mayster PDRN and place it in my face.
PDRN BENEFITS:
PDRN molecules are able to stimulate the metabolic activity of cells in your skin to regenerate collagen.
It can also stimulate wound recovery through boosting the rate of growth of fibroblasts, the cells mainly responsible for collagen production.
The activator in this set has glutathione which will brighten my skin as new tissue is encouraged to grow.
SCHEDULE:
-3PM PST TIKTOK LIVE PREP (numb up)
-4PM PST APP LIVE (application)
Monday “Katch Up” Walkie-Talkie
TODAY:
-3pm PST TIKTOK Prep
-4pm PST App LIVE (PDRN in Face + Melanatan 2 & Tirzepatide)
Find the APP linked in my profile or search “Natural Kaos” or Apple or Android.
Gain additional insight by following our app account, @natural.kaos.app
NEW YouTube @spa.and.tell
Life has become even busier due to this random goal I set for myself…
If I had contemplated this goal more I probably wouldn’t have started or shared it.
30 DAY GOALS:
-Walking 3 miles everyday takes me an hour.
-I alternate Hot Yoga and Weight Training each day, each of these activities takes me an hour or more.
-My Core challenge takes me 30-60 minutes as I learn how to do the exercises.
This scenario takes me 3 hours to complete daily. That’s a huge chunk of time and is causing me stress as I attempt to fit it all in…and yes I get tired too 🤣
I just keep telling myself it’s only 30 days you can do it.
The trick to this challenge is time management and I think that’s the insight I will glean from this next month.
Because of time restraints and a brand project I have this week…we are going to repurpose a video from the previous YouTube channel. I think it will be the microneedling scalp video.
Monday “Katch Up” Walkie-Talkie
TODAY:
-3pm PST TIKTOK Prep
-4pm PST App LIVE (PDRN in Face + Melanatan 2 & Tirzepatide)
Find the APP linked in my profile or search “Natural Kaos” or Apple or Android.
Gain additional insight by following our app account, @natural.kaos.app
NEW YouTube @spa.and.tell
Life has become even busier due to this random goal I set for myself…
If I had contemplated this goal more I probably wouldn’t have started or shared it.
30 DAY GOALS:
-Walking 3 miles everyday takes me an hour.
-I alternate Hot Yoga and Weight Training each day, each of these activities takes me an hour or more.
-My Core challenge takes me 30-60 minutes as I learn how to do the exercises.
This scenario takes me 3 hours to complete daily. That’s a huge chunk of time and is causing me stress as I attempt to fit it all in…and yes I get tired too 🤣
I just keep telling myself it’s only 30 days you can do it.
The trick to this challenge is time management and I think that’s the insight I will glean from this next month.
Because of time restraints and a brand project I have this week…we are going to repurpose a video from the previous YouTube channel. I think it will be the microneedling scalp video.
Just for laughs… it’s amazing to me what Ai auto captions will pull especially from the gym 😂
The music and the side conversations are combined into an interesting story…
Happy Friday
Just for laughs… it’s amazing to me what Ai auto captions will pull especially from the gym 😂
The music and the side conversations are combined into an interesting story…
Happy Friday
My 3 mile walking goal!
If you watched last nights YouTube video on lymphatic drainage you heard me explain my 30 day, 3 mile walking goal.
This was my third day in a row. I’m already scared 🙈 but I’m just going to take it day by day and fit it in where I can.
Tonight Tyler @tyler89libra will be doing a MESO LIVE in the app.
Then Rhonda @pancakequeen57 will be using threads LIVE in the app on Sunday in the app.
This weekend @fillerhouse_ is having a 41% off sale.
Monday I plan to use Mayster PDRN LIVE in the app.
Next Thursday will be my full Sculptra experience video.
My 3 mile walking goal!
If you watched last nights YouTube video on lymphatic drainage you heard me explain my 30 day, 3 mile walking goal.
This was my third day in a row. I’m already scared 🙈 but I’m just going to take it day by day and fit it in where I can.
Tonight Tyler @tyler89libra will be doing a MESO LIVE in the app.
Then Rhonda @pancakequeen57 will be using threads LIVE in the app on Sunday in the app.
This weekend @fillerhouse_ is having a 41% off sale.
Monday I plan to use Mayster PDRN LIVE in the app.
Next Thursday will be my full Sculptra experience video.
Comment “MASSAGE” for this YouTube video link.
🎥Can Lymphatic Drainage Massage Tone Your Abs And Decrease Inflammation?
Premiers tonight 4/18/24 at 5:15pm PST (8:15pm EST)
Those on FACEBOOK
https://urlgeni.us/youtube/LymphaticDrainageMassage
✅What are the benefits of Lymphatic Massage?
Our lymphatic system is key to our body’s immune defenses.
Lymphatic fluid flows through lymph vessels, which connect lymph nodes. White blood cells trap and destroy harmful particles, such as bacteria, as lymph fluid passes through lymph nodes.
Similar to blood in the circulatory system, lymphatic fluid is always moving. If it stops, fluid build-up can cause swelling, often in the arms or legs.
Exercise is crucial to avoid lymph fluid build-up, which is why walking is essential following surgery.
Combine walking with lymphatic drainage to encourage further movement and clearing of fluid.
If you are not post-surgery but feel inflamed, schedule a lymphatic drainage massage and start walking. It’s amazing what walking and light touch can do and how much better you will feel.
#abs #sculpted
Comment “MASSAGE” for this YouTube video link.
🎥Can Lymphatic Drainage Massage Tone Your Abs And Decrease Inflammation?
Premiers tonight 4/18/24 at 5:15pm PST (8:15pm EST)
Those on FACEBOOK
https://urlgeni.us/youtube/LymphaticDrainageMassage
✅What are the benefits of Lymphatic Massage?
Our lymphatic system is key to our body’s immune defenses.
Lymphatic fluid flows through lymph vessels, which connect lymph nodes. White blood cells trap and destroy harmful particles, such as bacteria, as lymph fluid passes through lymph nodes.
Similar to blood in the circulatory system, lymphatic fluid is always moving. If it stops, fluid build-up can cause swelling, often in the arms or legs.
Exercise is crucial to avoid lymph fluid build-up, which is why walking is essential following surgery.
Combine walking with lymphatic drainage to encourage further movement and clearing of fluid.
If you are not post-surgery but feel inflamed, schedule a lymphatic drainage massage and start walking. It’s amazing what walking and light touch can do and how much better you will feel.
#abs #sculpted
Hair Growth with Microneedling at Home
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https://youtu.be/JzwAnXfEKm8?si=oUiyDizrHay-W0-v Our App now offers Tirzepatide to App Members. It is prescribed by a US…
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Buy Terzepatide NowExclusive for Natural Kaos App Members! We have partnered with Beauty from Korea…
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https://youtu.be/nY-68C0ULBQ?si=xmEeAPFEkiY8nwrY Have you ever had skin that ached from inflammation? I have, and now I…
Affordable Bikini and Dress Try-On Summer 2024
https://www.youtube.com/live/7hLXZOV4UXs?si=3LGzTcLdkmIYFE0p Affordable Bikini and Dress Try-On Summer 2024 ITEMS LINKED BELOW… I’m 5’2″ and weigh…
