MOTS-c PEPTIDE

MOTS-c

What is MOTS-c?

MOTS-c or M O T S-c is a peptide. But it’s considered an MDP.

MDPs are short for Mitochondrial Derived Peptides. MDPs are found inside our Mitochondria.

I’m positive we are all familiar with DNA that is found inside our cell’s nucleus, but did you know that our mitochondria actually have their own DNA?

Our mitochondria have MITOCHONDRIAL DNA known as mtDNA, which can encode various proteins and peptides just like the DNA inside our nucleus.

MDPs are mitochondrial-derived peptides, meaning they are peptides made inside of your mitochondria using their own DNA.

I always wondered why Mitochondria had a squiggly frame in my physiology book. Like a winding lake, this provides more surface area between the inner and outer membrane, and it is via this space that energy is generated to power our mitochondria and, therefore, us.

How do Mitochondria create power?

Mitochondria are considered the Powerhouse of our cells. These are our mighty mini engines inside every cell, creating ATP. Further, every cell in your body can have between 1000 and 2500 mitochondria.

ATP cannot be stored, so Mitochondria need to be making a constant supply of ATP.

How is ATP created?

The creation of ATP begins with the Electron Transport Chain or Oxidative Phosphate.

Basically, it’s a proton pump, exchanging electrons and protons between the interior matrix and into the intermembrane.

Protons in this space need to move into the matrix but can only enter through the ATP Synthase channel. They are pushed into this channel by pressure that builds up behind the inner wall membrane, like a damn.

This creates kinetic energy, which becomes ATP, powering the mitochondria to create mitochondrial-derived peptides.

Youtube video on how this intermembrane pump works to make ATP

Inside the Mitochondria matrix, there are small open reading frames sORFs. These small circles encode functional microproteins called mitochondria-derived peptides (MDPs). These MDPs can stay inside mitochondria, enter the cytosol, translocate to the nucleus, or be secreted extracellularly to target tissues.

Now we understand that our Mitochondria make ATP, how they make energy, and that MOTSc is created by sORFs inside the matrix of the Mitochondria.

How was it discovered?

MOTS-c is one of three identified MDPs.

Humanin was the first MDP discovered.

Scientists began looking at Mitochondria for aging because of its role in cellular energy and cell signaling. This is due to the mitochondrial dysfunction observed in Alzheimer’s and Parkinson’s disease. Apparently, our brain tissue is mitochondria-rich and is highly sensitive to any mitochondrial changes.

Mitochondria dysfunction is also linked to obesity, and further Cancer is linked to mitochondrial DNA instability.

As they have identified these MDPs MOTS-c has stood out.

Reserach began on MOTS-c in 2015. These small peptides made inside our Mitochondria signal different pathways and MOTS-c is special because it has been shown to mimic exercise and prevent muscle atrophy.

Screenshot-2024-02-13-at-90230 PM - Natural Kaos

How does it work?

MOTS-c stands out because it communicates between the mitochondria and the nucleus. And it is encoded with mitochondrial DNA.

Researchers have found the highest levels of MOTS-c in the young and the highest concentrations of this peptide inside skeletal muscle cells.

TRANSLOCATION

When MOTS-c moves from the mitochondria to the nucleus, it activates the AMPK pathway.

AMPK is a sensor inside the nucleus that is in charge of making sure there is enough ATP.

AMPK

Once activated, AMPK increases fatty acid oxidation. This increases fat burning and glycolysis, the breakdown of sugars.

The flow of MOTS-c into the nucleus turns on energy use.

One way to stimulate the flow of MOTS-c is with exercise, and this is why higher levels are found inside skeletal muscle cells. Muscle cells require more energy.

We want AMPK initiated because it also shuts down acetyl-CoA carboxylase. This enzyme signals our body to convert triglycerides into fatty acids and store them in our liver and fat cells.

Our entire glucose breakdown and energy production begins with MOTS-c. Because the presence of MOTS-c optimizes energy, thereby optimizing our cells for production.

It’s similar to gas for your car.

This is why AMPK-triggering drugs are considered an exercise in a pill or injection.

Metformin acts as an AMPK activator but has side effects.

MOTS-c is reported to have the following benefits:

Increases energy burning, and lowers the pool of glucose that would normally be stored.
When AMPK is activated by MOTS-c, it stimulates the creation and clearance of new and old mitochondria, by maintaining balance and optimizing the healthiest mitochondria.
MOTS-c Increases NAD+ levels
MOTS-c decreases the loss of dermal collagen.
Improves Insulin Sensity
Improves muscle health

Hope this helps- follow me along my journey where I dose and inject inside the Natural Kaos App, we also have a large Peptide group where we share supplies and information that helps others on their peptide journey! – KIM

Screenshot-2024-02-07-at-23051 PM - Natural Kaos

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Do you want to know how I did it? How did I transform my skin? 🤔

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⚡ The Natural Kaos community will help you find the right products for your skin type.
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🔎 Try out different products and devices to get smooth and flawless skin.
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🔗 Comment “SKIN” and I will send you the link myself!

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One month test with Omnilux LED, comment “VIDEO” and I’ll send you the video that will premier at 5:15pm PST on @spa.and.tell YouTube channel.

I filmed and created this video 3 years ago…I thought I had posted it already…obviously I was wrong.

I hope my test of the face and neck led masks from @omniluxled helps you navigate the LED landscape.

RED LED 🎥 https://urlgeni.us/youtube/Omnilux

#redled #redlighttherapy #redlighttherapybenefits #omnilux

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One month test with Omnilux LED, comment “VIDEO” and I’ll send you the video that will premier at 5:15pm PST on @spa.and.tell YouTube channel.

I filmed and created this video 3 years ago…I thought I had posted it already…obviously I was wrong.

I hope my test of the face and neck led masks from @omniluxled helps you navigate the LED landscape.

RED LED 🎥 https://urlgeni.us/youtube/Omnilux

#redled #redlighttherapy #redlighttherapybenefits #omnilux

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Who told you Micro-needling doesn’t work? 🤦

Do you want to know how I did it? How did I transform my skin? 🤔

Check out my app Natural Kaos! 🚀

⚡ The Natural Kaos community will help you find the right products for your skin type.
🤝 Learn from your peers and their experiences.
🔎 Try out different products and devices to get smooth and flawless skin.
💲 Find discounts on your favorite skincare products from our app.
✍ Sign up today!
🔗 Comment “SKIN” and I will send you the link myself!

#skincareroutine #glowup #skincaretips #beautytips #healthyskin #flawlessskin #skincarecommunity #radiantskin #skincareaddict #skincareproducts #naturalskincare #skincaregoals #selfcare #beautyroutine #skincareproducts #skincareessentials #skincareobsessed #skincarejourney #skincarehacks #clearskin #youthfulskin #skincareregimen #beautydevices #antiaging #facecare #skincarescience #dermatology #beautytech #skincareapp #skincareproducts

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Comment “LINK” to get your skincare questions answered asap and help me train our new friend.

Because I proliferate content, my website is deep with info, videos, sourcing, and promo codes.
Although a treasure trove of information it can be overwhelming and hard to find what you are looking for.

Today, I stepped into the Ai creation world and built my first assistant. The NK Web Assistant has crawled my site and I spent a few hours training it. I also added the most asked questions I see, such as:

-Where do you source tox?
-Where are the peptides?
-Where are microneedling videos?
-Where is numbing cream?
-What is mesotherapy?
-Are KFDA-approved products safe?
-How do I find the promo codes?
-Why should I join the NK APP?

There is only one of me 😂 however, I care about promptly responding to you. This 🤖 is going to truly help expedite the conversation and serve you!

Also, if you have an iPhone📱 (I’m not sure about Android as I don’t have one) you can save the site that the link takes you to as an Icon on your home screen. I placed mine next to the Natural Kaos App.

As you ask the NK 🤖 questions it learns. It’s built using the latest technology (well at least that I can navigate) called:

Artificial General Intelligence (AGI). It refers to a type of AI that has the ability to understand, learn, and apply knowledge across a wide range of tasks at a level comparable to human intelligence. Unlike narrow AI, which is designed for specific tasks, AGI aims to perform any intellectual task that a human can do.

If you are on FACEBOOK here is the NK 🤖 link
https://urlgeni.us/NKwebAssistant

#skincareroutine #glowup #skincaretips #beautytips #flawlessskin #skincarecommunity #radiantskin #skincareaddict #skincareproducts #skincaregoals #beautyroutine #skincareproducts #skincareessentials #skincareobsessed #skincarejourney #skincarehacks #youthfulskin #skincareregimen #beautydevices #antiaging #skincarescience #beautytech #skincareapp #skincareproducts
#aihelper #mindos #myfirsrai #trainingai #naturalkaos

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Comment “LINK” to get your skincare questions answered asap and help me train our new friend.

Because I proliferate content, my website is deep with info, videos, sourcing, and promo codes.
Although a treasure trove of information it can be overwhelming and hard to find what you are looking for.

Today, I stepped into the Ai creation world and built my first assistant. The NK Web Assistant has crawled my site and I spent a few hours training it. I also added the most asked questions I see, such as:

-Where do you source tox?
-Where are the peptides?
-Where are microneedling videos?
-Where is numbing cream?
-What is mesotherapy?
-Are KFDA-approved products safe?
-How do I find the promo codes?
-Why should I join the NK APP?

There is only one of me 😂 however, I care about promptly responding to you. This 🤖 is going to truly help expedite the conversation and serve you!

Also, if you have an iPhone📱 (I’m not sure about Android as I don’t have one) you can save the site that the link takes you to as an Icon on your home screen. I placed mine next to the Natural Kaos App.

As you ask the NK 🤖 questions it learns. It’s built using the latest technology (well at least that I can navigate) called:

Artificial General Intelligence (AGI). It refers to a type of AI that has the ability to understand, learn, and apply knowledge across a wide range of tasks at a level comparable to human intelligence. Unlike narrow AI, which is designed for specific tasks, AGI aims to perform any intellectual task that a human can do.

If you are on FACEBOOK here is the NK 🤖 link
https://urlgeni.us/NKwebAssistant

#skincareroutine #glowup #skincaretips #beautytips #flawlessskin #skincarecommunity #radiantskin #skincareaddict #skincareproducts #skincaregoals #beautyroutine #skincareproducts #skincareessentials #skincareobsessed #skincarejourney #skincarehacks #youthfulskin #skincareregimen #beautydevices #antiaging #skincarescience #beautytech #skincareapp #skincareproducts
#aihelper #mindos #myfirsrai #trainingai #naturalkaos

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Comment “DILL” for both the dressing and chicken recipe:)

This is the Dill Dip Dressing Recipe that my sister @sweetnsassyeats makes for us each year on our houseboat trip!

You can thin it out with more or less mayonnaise. It keeps perfectly in the fridge for these hot summer days. It’s an adult and kid pleaser plus exposes your kids to more varieties than simply ranch dip.

#kidfavorites #dilldressing #dilldip #dillrecipes #dressingrecipe #hiddenvalley #hiddenvalleyranch #summersalad #summerfood #summerrecipes

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Comment “DILL” for both the dressing and chicken recipe:)

This is the Dill Dip Dressing Recipe that my sister @sweetnsassyeats makes for us each year on our houseboat trip!

You can thin it out with more or less mayonnaise. It keeps perfectly in the fridge for these hot summer days. It’s an adult and kid pleaser plus exposes your kids to more varieties than simply ranch dip.

#kidfavorites #dilldressing #dilldip #dillrecipes #dressingrecipe #hiddenvalley #hiddenvalleyranch #summersalad #summerfood #summerrecipes

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I try my best to share and answer your Semaglutide questions…Comment “APP” for my Natural Kaos App link, plus the peptide book and my weight loss videos explaining how I used Semaglutide last year.

Sourcing Semaglutide and the tools I use to reconstitute are found in my App. I DO NOT answer these questions publicly due to censorship. If you want this information you need to have personal responsibility and the initial step is to join the Natural Kaos App.

I appreciate your understanding. We are excited for you to join the thousands of us who use these peptides plus everything else I and others share.

Our App is not a “Kim Show” nor is it static! Rather it is a thriving community of people like me sharing these concepts and how they are working. It’s the world’s largest DIY “how to” skincare community and it’s unlike anything else you’ve ever experienced.

If you want these products for penny’s on the dollar with videos on how to use them then we will see you in the App.

If you want blogs on this content you can always visit www.naturalkaos.com

Again, comment “APP” and you will receive this detail in your DM inbox.

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I try my best to share and answer your Semaglutide questions…Comment “APP” for my Natural Kaos App link, plus the peptide book and my weight loss videos explaining how I used Semaglutide last year.

Sourcing Semaglutide and the tools I use to reconstitute are found in my App. I DO NOT answer these questions publicly due to censorship. If you want this information you need to have personal responsibility and the initial step is to join the Natural Kaos App.

I appreciate your understanding. We are excited for you to join the thousands of us who use these peptides plus everything else I and others share.

Our App is not a “Kim Show” nor is it static! Rather it is a thriving community of people like me sharing these concepts and how they are working. It’s the world’s largest DIY “how to” skincare community and it’s unlike anything else you’ve ever experienced.

If you want these products for penny’s on the dollar with videos on how to use them then we will see you in the App.

If you want blogs on this content you can always visit www.naturalkaos.com

Again, comment “APP” and you will receive this detail in your DM inbox.

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Paying For EXPENSIVE treatments ❌,
LEARN How to Do It Yourself ✅

Do you want to buy your favorite skincare products, but they are burning a hole in your pocket? 😟

Try our app, Natural Kaos, where you can find discounts and promos deals for the major skincare brands! 🌟

⚡ The Natural Kaos community will help you find the right products for your skin type.
🤝 Learn from your peers and their experiences.
🔎 Try out different products and devices to get smooth and flawless skin.
💲 Find discounts on your favorite skincare products from our app.
✍ Sign up today!
🔗 Comment “SKIN” and I will send you the link myself!

#skincareroutine #glowup #skincaretips #beautytips #healthyskin #flawlessskin #skincarecommunity #radiantskin #skincareaddict #skincareproducts #naturalskincare #skincaregoals #selfcare #beautyroutine #skincareproducts #skincareessentials #skincareobsessed #skincarejourney #skincarehacks #clearskin #youthfulskin #skincareregimen #beautydevices #antiaging #facecare #skincarescience #dermatology #beautytech #skincareapp #skincareproducts

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Happy Sunday!!!

I brought the boys to Napa today to visit the gardens at the Culinary Institute of America.
There is incredible inspiration here, from the infrastructure, to the combinations of plantings.
The boys were excited to see what they could do and create in our own garden…which unfortunately has been greatly neglected this year.
I reminded them there is always next year!

What is CIA (Culinary Institute of America)?

CIA at Copia is the Culinary Institute of America’s food and beverage hub in the heart of Napa. Explore food and wine through a variety of dining experiences, hands-on classes, shopping, and more.

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