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MOTS-c PEPTIDE

MOTS-c

What is MOTS-c?

MOTS-c or M O T S-c is a peptide. But it’s considered an MDP.

MDPs are short for Mitochondrial Derived Peptides. MDPs are found inside our Mitochondria.

I’m positive we are all familiar with DNA that is found inside our cell’s nucleus, but did you know that our mitochondria actually have their own DNA?

Our mitochondria have MITOCHONDRIAL DNA known as mtDNA, which can encode various proteins and peptides just like the DNA inside our nucleus.

MDPs are mitochondrial-derived peptides, meaning they are peptides made inside of your mitochondria using their own DNA.

I always wondered why Mitochondria had a squiggly frame in my physiology book. Like a winding lake, this provides more surface area between the inner and outer membrane, and it is via this space that energy is generated to power our mitochondria and, therefore, us.

How do Mitochondria create power?

Mitochondria are considered the Powerhouse of our cells. These are our mighty mini engines inside every cell, creating ATP. Further, every cell in your body can have between 1000 and 2500 mitochondria.

ATP cannot be stored, so Mitochondria need to be making a constant supply of ATP.

How is ATP created?

The creation of ATP begins with the Electron Transport Chain or Oxidative Phosphate.

Basically, it’s a proton pump, exchanging electrons and protons between the interior matrix and into the intermembrane.

Protons in this space need to move into the matrix but can only enter through the ATP Synthase channel. They are pushed into this channel by pressure that builds up behind the inner wall membrane, like a damn.

This creates kinetic energy, which becomes ATP, powering the mitochondria to create mitochondrial-derived peptides.

Youtube video on how this intermembrane pump works to make ATP

Inside the Mitochondria matrix, there are small open reading frames sORFs. These small circles encode functional microproteins called mitochondria-derived peptides (MDPs). These MDPs can stay inside mitochondria, enter the cytosol, translocate to the nucleus, or be secreted extracellularly to target tissues.

Now we understand that our Mitochondria make ATP, how they make energy, and that MOTSc is created by sORFs inside the matrix of the Mitochondria.

How was it discovered?

MOTS-c is one of three identified MDPs.

Humanin was the first MDP discovered.

Scientists began looking at Mitochondria for aging because of its role in cellular energy and cell signaling. This is due to the mitochondrial dysfunction observed in Alzheimer’s and Parkinson’s disease. Apparently, our brain tissue is mitochondria-rich and is highly sensitive to any mitochondrial changes.

Mitochondria dysfunction is also linked to obesity, and further Cancer is linked to mitochondrial DNA instability.

As they have identified these MDPs MOTS-c has stood out.

Reserach began on MOTS-c in 2015. These small peptides made inside our Mitochondria signal different pathways and MOTS-c is special because it has been shown to mimic exercise and prevent muscle atrophy.

How does it work?

MOTS-c stands out because it communicates between the mitochondria and the nucleus. And it is encoded with mitochondrial DNA.

Researchers have found the highest levels of MOTS-c in the young and the highest concentrations of this peptide inside skeletal muscle cells.

TRANSLOCATION

When MOTS-c moves from the mitochondria to the nucleus, it activates the AMPK pathway.

AMPK is a sensor inside the nucleus that is in charge of making sure there is enough ATP.

AMPK 

Once activated, AMPK increases fatty acid oxidation. This increases fat burning and glycolysis, the breakdown of sugars.

The flow of MOTS-c into the nucleus turns on energy use.

One way to stimulate the flow of MOTS-c is with exercise, and this is why higher levels are found inside skeletal muscle cells. Muscle cells require more energy.

We want AMPK initiated because it also shuts down acetyl-CoA carboxylase. This enzyme signals our body to convert triglycerides into fatty acids and store them in our liver and fat cells.

Our entire glucose breakdown and energy production begins with MOTS-c. Because the presence of MOTS-c optimizes energy, thereby optimizing our cells for production.

It’s similar to gas for your car.

This is why AMPK-triggering drugs are considered an exercise in a pill or injection.

Metformin acts as an AMPK activator but has side effects.

MOTS-c is reported to have the following benefits:

  1. Increases energy burning, and lowers the pool of glucose that would normally be stored.
  2. When AMPK is activated by MOTS-c, it stimulates the creation and clearance of new and old mitochondria, by maintaining balance and optimizing the healthiest mitochondria.
  3. MOTS-c Increases NAD+ levels
  4. MOTS-c decreases the loss of dermal collagen.
  5. Improves Insulin Sensity
  6. Improves muscle health

Hope this helps- follow me along my journey where I dose and inject inside the Natural Kaos App, we also have a large Peptide group where we share supplies and information that helps others on their peptide journey! – KIM

NATURAL KAOS APP LINKS:

APPLE

ANDROID


Comment “LAKE” for today’s Lake Powell vlog video. I’ve shared our Lake Powell Family Trip for years…I asked while I was on the Lake what you would want to see?

After your feedback, I filmed what a full day on Lake Powell includes. If you love the water and lake life it doesn’t get better than Lake Powell…it’s another planet. It’s also the BEST way to enjoy the Grand Canyon. The massive benefit to Lake Powell is how HUGE this body of water is…providing so much space to enjoy and explore. Forget about crowded lakes…I live next to a now very crowded lake…it wasn’t crowded when I was growing up but it’s become crazy these days!
This is the reason making the 14 hour drive to Lake Powell annually is worth it!

I hope this Lake Powell Day Vlog gives you insight and an appreciation for this very unique lake.

This is not my boat! It’s my dad’s boat and he gives us this amazing experience each year. His boat is not for rent (I get this Q each year), however in last years Lake Powell video I explain that @antelopepoint they do have houseboat rentals. 

If you are interested in buying a boat similar to the @adonia_yachts that we use then check out @sunrisepeakhouseboats they offer shares on these types of boats.

Facebook 🎥 https://urlgeni.us/youtube/LakePowell2024

#lakepowell #lakepowellhouseboats #houseboat #houseboatlife #antelopecanyon #lakelife

Comment “LAKE” for today’s Lake Powell vlog video. I’ve shared our Lake Powell Family Trip for years…I asked while I was on the Lake what you would want to see?

After your feedback, I filmed what a full day on Lake Powell includes. If you love the water and lake life it doesn’t get better than Lake Powell…it’s another planet. It’s also the BEST way to enjoy the Grand Canyon. The massive benefit to Lake Powell is how HUGE this body of water is…providing so much space to enjoy and explore. Forget about crowded lakes…I live next to a now very crowded lake…it wasn’t crowded when I was growing up but it’s become crazy these days!
This is the reason making the 14 hour drive to Lake Powell annually is worth it!

I hope this Lake Powell Day Vlog gives you insight and an appreciation for this very unique lake.

This is not my boat! It’s my dad’s boat and he gives us this amazing experience each year. His boat is not for rent (I get this Q each year), however in last years Lake Powell video I explain that @antelopepoint they do have houseboat rentals.

If you are interested in buying a boat similar to the @adonia_yachts that we use then check out @sunrisepeakhouseboats they offer shares on these types of boats.

Facebook 🎥 https://urlgeni.us/youtube/LakePowell2024

#lakepowell #lakepowellhouseboats #houseboat #houseboatlife #antelopecanyon #lakelife

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Natural Gua-Sha Hack 🥒

Do you want to know more hacks about skincare? 🤔

Check out my app Natural Kaos! 🚀

⚡ The Natural Kaos community will help you find the right products for your skin type.
🤝 Learn from your peers and their experiences.
🔎 Try out different products and devices to get smooth and flawless skin.
💲 Find discounts on your favorite skincare products from our app.
✍ Sign up today!
🔗 Comment “SKIN” and I will send you the link myself!

#skincareroutine #glowup #skincaretips #beautytips #healthyskin #flawlessskin #skincarecommunity #radiantskin #skincareaddict #skincareproducts #naturalskincare #skincaregoals #selfcare #beautyroutine #skincareproducts #skincareessentials #skincareobsessed #skincarejourney #skincarehacks #clearskin #youthfulskin #skincareregimen #beautydevices #antiaging #facecare #skincarescience #dermatology #beautytech #skincareapp #skincareproducts

Natural Gua-Sha Hack 🥒

Do you want to know more hacks about skincare? 🤔

Check out my app Natural Kaos! 🚀

⚡ The Natural Kaos community will help you find the right products for your skin type.
🤝 Learn from your peers and their experiences.
🔎 Try out different products and devices to get smooth and flawless skin.
💲 Find discounts on your favorite skincare products from our app.
✍ Sign up today!
🔗 Comment “SKIN” and I will send you the link myself!

#skincareroutine #glowup #skincaretips #beautytips #healthyskin #flawlessskin #skincarecommunity #radiantskin #skincareaddict #skincareproducts #naturalskincare #skincaregoals #selfcare #beautyroutine #skincareproducts #skincareessentials #skincareobsessed #skincarejourney #skincarehacks #clearskin #youthfulskin #skincareregimen #beautydevices #antiaging #facecare #skincarescience #dermatology #beautytech #skincareapp #skincareproducts

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Comment “SWIM” for a list of affordable swimsuits from Amazon. These are the bikinis I took to Lake Powell.

A day at Lake Powell video will air tomorrow on the @spa.and.tell YouTube channel.

Comment “SWIM” for a list of affordable swimsuits from Amazon. These are the bikinis I took to Lake Powell.

A day at Lake Powell video will air tomorrow on the @spa.and.tell YouTube channel.

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My Action Plan to go from that skin to my healthy skin now: 👇

Diet:
Meat Focused
Colostrum
Drinking 3-4 liters of water every day
Lifting or Yoga daily, plus a 3 mile walk

Procedures:
Microneedling
TCA Peels
Nira Laser
Radio Frequency
Mesotherapy

Products:
SPF
Vitamin C
Glycolic and Salicylic Acids
Tretinoin
Tox

Do you want to know more hacks about skincare? 🤔

Check out my app Natural Kaos! 🚀

⚡ The Natural Kaos community will help you find the right products for your skin type.
🤝 Learn from your peers and their experiences.
🔎 Try out different products and devices to get smooth and flawless skin.
💲 Find discounts on your favorite skincare products from our app.
✍ Sign up today!
🔗 Comment “SKIN” and I will send you the link myself!

#skincareroutine #glowup #skincaretips #beautytips #healthyskin #flawlessskin #skincarecommunity #radiantskin #skincareaddict #skincareproducts #naturalskincare #skincaregoals #selfcare #beautyroutine #skincareproducts #skincareessentials #skincareobsessed #skincarejourney #skincarehacks #clearskin #youthfulskin #skincareregimen #beautydevices #antiaging #facecare #skincarescience #dermatology #beautytech #skincareapp #skincareproducts

My Action Plan to go from that skin to my healthy skin now: 👇

Diet:
Meat Focused
Colostrum
Drinking 3-4 liters of water every day
Lifting or Yoga daily, plus a 3 mile walk

Procedures:
Microneedling
TCA Peels
Nira Laser
Radio Frequency
Mesotherapy

Products:
SPF
Vitamin C
Glycolic and Salicylic Acids
Tretinoin
Tox

Do you want to know more hacks about skincare? 🤔

Check out my app Natural Kaos! 🚀

⚡ The Natural Kaos community will help you find the right products for your skin type.
🤝 Learn from your peers and their experiences.
🔎 Try out different products and devices to get smooth and flawless skin.
💲 Find discounts on your favorite skincare products from our app.
✍ Sign up today!
🔗 Comment “SKIN” and I will send you the link myself!

#skincareroutine #glowup #skincaretips #beautytips #healthyskin #flawlessskin #skincarecommunity #radiantskin #skincareaddict #skincareproducts #naturalskincare #skincaregoals #selfcare #beautyroutine #skincareproducts #skincareessentials #skincareobsessed #skincarejourney #skincarehacks #clearskin #youthfulskin #skincareregimen #beautydevices #antiaging #facecare #skincarescience #dermatology #beautytech #skincareapp #skincareproducts

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You’ve been waiting, and the SALE is on, 15% OFF with the code KIMPRATT

Comment “NIRA” for the discount link sent to your DM inbox.

Get more life out of your TOX injections…you know that liquid that I’m not allowed to say…but starts with a “B” and stops wrinkles! Using the Nira in combo with injectables will give you the skin and firmness you’ve been dreaming of…I personally know…just watch my thousands of videos as proof!

With a large enough tip to treat the full face in just 3 minutes a day, NIRA Pro is the fastest and most powerful, painless at-home laser that is FDA-cleared and clinically proven to reduce fine lines and wrinkles.

In just minutes a day, you can treat your full face, neck, chest, and back of hands for clinical-grade results in the comfort of your home.
200x more powerful than LED devices, our skin-renewing laser utilizes patented technology to deliver the most innovative beauty device of the decade!

Developed by laser experts, NIRA Pro is truly one of a kind. Bring the med spa home for visibly firmer, youthful-looking skin in 90 days guaranteed, or get your money back!

Customers have seen improvements in:
-skin tone
-skin texture
-wrinkles
-sagging skin

These links for 15% off are active 7/15/24 - 7/21/24.  Comment “NIRA”

#nirasale #niraskin #nirapro #collageninductiontherapy #firmerskin #tighterskin #wrinklefree

You’ve been waiting, and the SALE is on, 15% OFF with the code KIMPRATT

Comment “NIRA” for the discount link sent to your DM inbox.

Get more life out of your TOX injections…you know that liquid that I’m not allowed to say…but starts with a “B” and stops wrinkles! Using the Nira in combo with injectables will give you the skin and firmness you’ve been dreaming of…I personally know…just watch my thousands of videos as proof!

With a large enough tip to treat the full face in just 3 minutes a day, NIRA Pro is the fastest and most powerful, painless at-home laser that is FDA-cleared and clinically proven to reduce fine lines and wrinkles.

In just minutes a day, you can treat your full face, neck, chest, and back of hands for clinical-grade results in the comfort of your home.
200x more powerful than LED devices, our skin-renewing laser utilizes patented technology to deliver the most innovative beauty device of the decade!

Developed by laser experts, NIRA Pro is truly one of a kind. Bring the med spa home for visibly firmer, youthful-looking skin in 90 days guaranteed, or get your money back!

Customers have seen improvements in:
-skin tone
-skin texture
-wrinkles
-sagging skin

These links for 15% off are active 7/15/24 – 7/21/24.  Comment “NIRA”

#nirasale #niraskin #nirapro #collageninductiontherapy #firmerskin #tighterskin #wrinklefree

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Welcome to Day in the Life of 🎬 Content Creator, 💼 Business Owner, and Mother! 👑

Do you want to know more? 🤔

Check out my app Natural Kaos! 🚀

⚡ The Natural Kaos community will help you find the right products for your skin type.
🤝 Learn from your peers and their experiences.
🔎 Try out different products and devices to get smooth and flawless skin.
💲 Find discounts on your favorite skincare products from our app.
✍ Sign up today!
🔗 Comment “SKIN” and I will send you the link myself!

#skincareroutine #glowup #skincaretips #beautytips #healthyskin #flawlessskin #skincarecommunity #radiantskin #skincareaddict #skincareproducts #naturalskincare #skincaregoals #selfcare #beautyroutine #skincareproducts #skincareessentials #skincareobsessed #skincarejourney #skincarehacks #clearskin #youthfulskin #skincareregimen #beautydevices #antiaging #facecare #skincarescience #dermatology #beautytech #skincareapp #skincareproducts

Welcome to Day in the Life of 🎬 Content Creator, 💼 Business Owner, and Mother! 👑

Do you want to know more? 🤔

Check out my app Natural Kaos! 🚀

⚡ The Natural Kaos community will help you find the right products for your skin type.
🤝 Learn from your peers and their experiences.
🔎 Try out different products and devices to get smooth and flawless skin.
💲 Find discounts on your favorite skincare products from our app.
✍ Sign up today!
🔗 Comment “SKIN” and I will send you the link myself!

#skincareroutine #glowup #skincaretips #beautytips #healthyskin #flawlessskin #skincarecommunity #radiantskin #skincareaddict #skincareproducts #naturalskincare #skincaregoals #selfcare #beautyroutine #skincareproducts #skincareessentials #skincareobsessed #skincarejourney #skincarehacks #clearskin #youthfulskin #skincareregimen #beautydevices #antiaging #facecare #skincarescience #dermatology #beautytech #skincareapp #skincareproducts

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🖐️ Hi, I am Kim Pratt! Founder of Natural Kaos and mother of 4 boys! ✨

Do you want to know more hacks about skincare? 🤔

Check out my app Natural Kaos! 🚀

⚡ The Natural Kaos community will help you find the right products for your skin type. 
🤝 Learn from your peers and their experiences.
🔎 Try out different products and devices to get smooth and flawless skin.
💲 Find discounts on your favorite skincare products from our app.
✍ Sign up today!
🔗 Comment “SKIN” and I will send you the link myself!

#skincareroutine #glowup #skincaretips #beautytips #healthyskin #flawlessskin #skincarecommunity #radiantskin #skincareaddict #skincareproducts #naturalskincare #skincaregoals #selfcare #beautyroutine #skincareproducts #skincareessentials #skincareobsessed #skincarejourney #skincarehacks #clearskin #youthfulskin #skincareregimen #beautydevices #antiaging #facecare #skincarescience #dermatology #beautytech #skincareapp #skincareproducts

🖐️ Hi, I am Kim Pratt! Founder of Natural Kaos and mother of 4 boys! ✨

Do you want to know more hacks about skincare? 🤔

Check out my app Natural Kaos! 🚀

⚡ The Natural Kaos community will help you find the right products for your skin type.
🤝 Learn from your peers and their experiences.
🔎 Try out different products and devices to get smooth and flawless skin.
💲 Find discounts on your favorite skincare products from our app.
✍ Sign up today!
🔗 Comment “SKIN” and I will send you the link myself!

#skincareroutine #glowup #skincaretips #beautytips #healthyskin #flawlessskin #skincarecommunity #radiantskin #skincareaddict #skincareproducts #naturalskincare #skincaregoals #selfcare #beautyroutine #skincareproducts #skincareessentials #skincareobsessed #skincarejourney #skincarehacks #clearskin #youthfulskin #skincareregimen #beautydevices #antiaging #facecare #skincarescience #dermatology #beautytech #skincareapp #skincareproducts

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