MOTS-c
What is MOTS-c?
MOTS-c or M O T S-c is a peptide. But it’s considered an MDP.
MDPs are short for Mitochondrial Derived Peptides. MDPs are found inside our Mitochondria.
I’m positive we are all familiar with DNA that is found inside our cell’s nucleus, but did you know that our mitochondria actually have their own DNA?
Our mitochondria have MITOCHONDRIAL DNA known as mtDNA, which can encode various proteins and peptides just like the DNA inside our nucleus.
MDPs are mitochondrial-derived peptides, meaning they are peptides made inside of your mitochondria using their own DNA.
I always wondered why Mitochondria had a squiggly frame in my physiology book. Like a winding lake, this provides more surface area between the inner and outer membrane, and it is via this space that energy is generated to power our mitochondria and, therefore, us.
How do Mitochondria create power?
Mitochondria are considered the Powerhouse of our cells. These are our mighty mini engines inside every cell, creating ATP. Further, every cell in your body can have between 1000 and 2500 mitochondria.
ATP cannot be stored, so Mitochondria need to be making a constant supply of ATP.
How is ATP created?
The creation of ATP begins with the Electron Transport Chain or Oxidative Phosphate.
Basically, it’s a proton pump, exchanging electrons and protons between the interior matrix and into the intermembrane.
Protons in this space need to move into the matrix but can only enter through the ATP Synthase channel. They are pushed into this channel by pressure that builds up behind the inner wall membrane, like a damn.
This creates kinetic energy, which becomes ATP, powering the mitochondria to create mitochondrial-derived peptides.
Youtube video on how this intermembrane pump works to make ATP
Inside the Mitochondria matrix, there are small open reading frames sORFs. These small circles encode functional microproteins called mitochondria-derived peptides (MDPs). These MDPs can stay inside mitochondria, enter the cytosol, translocate to the nucleus, or be secreted extracellularly to target tissues.
Now we understand that our Mitochondria make ATP, how they make energy, and that MOTSc is created by sORFs inside the matrix of the Mitochondria.
How was it discovered?
MOTS-c is one of three identified MDPs.
Humanin was the first MDP discovered.
Scientists began looking at Mitochondria for aging because of its role in cellular energy and cell signaling. This is due to the mitochondrial dysfunction observed in Alzheimer’s and Parkinson’s disease. Apparently, our brain tissue is mitochondria-rich and is highly sensitive to any mitochondrial changes.
Mitochondria dysfunction is also linked to obesity, and further Cancer is linked to mitochondrial DNA instability.
As they have identified these MDPs MOTS-c has stood out.
Reserach began on MOTS-c in 2015. These small peptides made inside our Mitochondria signal different pathways and MOTS-c is special because it has been shown to mimic exercise and prevent muscle atrophy.
How does it work?
MOTS-c stands out because it communicates between the mitochondria and the nucleus. And it is encoded with mitochondrial DNA.
Researchers have found the highest levels of MOTS-c in the young and the highest concentrations of this peptide inside skeletal muscle cells.
TRANSLOCATION
When MOTS-c moves from the mitochondria to the nucleus, it activates the AMPK pathway.
AMPK is a sensor inside the nucleus that is in charge of making sure there is enough ATP.
AMPK
Once activated, AMPK increases fatty acid oxidation. This increases fat burning and glycolysis, the breakdown of sugars.
The flow of MOTS-c into the nucleus turns on energy use.
One way to stimulate the flow of MOTS-c is with exercise, and this is why higher levels are found inside skeletal muscle cells. Muscle cells require more energy.
We want AMPK initiated because it also shuts down acetyl-CoA carboxylase. This enzyme signals our body to convert triglycerides into fatty acids and store them in our liver and fat cells.
Our entire glucose breakdown and energy production begins with MOTS-c. Because the presence of MOTS-c optimizes energy, thereby optimizing our cells for production.
It’s similar to gas for your car.
This is why AMPK-triggering drugs are considered an exercise in a pill or injection.
Metformin acts as an AMPK activator but has side effects.
MOTS-c is reported to have the following benefits:
- Increases energy burning, and lowers the pool of glucose that would normally be stored.
- When AMPK is activated by MOTS-c, it stimulates the creation and clearance of new and old mitochondria, by maintaining balance and optimizing the healthiest mitochondria.
- MOTS-c Increases NAD+ levels
- MOTS-c decreases the loss of dermal collagen.
- Improves Insulin Sensity
- Improves muscle health
Hope this helps- follow me along my journey where I dose and inject inside the Natural Kaos App, we also have a large Peptide group where we share supplies and information that helps others on their peptide journey! – KIM
NATURAL KAOS APP LINKS:
ANDROID
I realize that some procedures look shocking…Mesotherapy requires many, many pricks.
After a session, I look crazy, or people think I enjoy pain.
THIS IS FALSE
During child birth I needed an epidural with all four deliveries!
I don’t have a high pain tolerance; however, over the years, I’ve developed stamina for the pain.
I enjoy that in our app; we commiserate about all of these aspects of doing professional skincare at home.
I’ve had mesotherapy done professionally, and it’s brutal in professional hands, too. It’s simply the nature of this procedure. I’ve found I can stomach the pain easier if I’m in charge of it.
While I was in Korea, I kept telling my injector that I didn’t want anymore and that whatever was placed was enough for me.
I tried to bow out early, but she insisted I needed to keep going 😂🙈.
If you’ve ever seen my Korean Thread Video, you know I was trying to escape!
KOREAN THREAD 🎥
https://urlgeni.us/youtube/PDOThreads
The point I want to offer is that not all at-home beauty treatments are as painful as mesotherapy. The major reason Mesotherapy is painful is that you have large areas of skin to cover. You can use numbing cream to take a bit of the bite off, but even 12% topical lido is not going to fully numb you. Some pokes are easy, and others painful.
Mid-face and lip areas are by far my most sensitive regions, and each time I make it through, I feel like a superhero 🦸♀️😅.
I’m motivated by the convenience of performing these procedures at home. Although I don’t look forward to the pain of mesotherapy, I’m always encouraged by the benefits these products have for my skin.
I love the ability and freedom to choose for myself, and I appreciate it when others feel empowered as well.
I’ve never infered that my life choices are suitable for everyone; only that options exist, and that’s why I share.
My community, found inside the Natural Kaos App, is where these procedures take place.
NATURAL KAOS APP
https://urlgeni.us/AppInstall
I realize that some procedures look shocking…Mesotherapy requires many, many pricks.
After a session, I look crazy, or people think I enjoy pain.
THIS IS FALSE
During child birth I needed an epidural with all four deliveries!
I don’t have a high pain tolerance; however, over the years, I’ve developed stamina for the pain.
I enjoy that in our app; we commiserate about all of these aspects of doing professional skincare at home.
I’ve had mesotherapy done professionally, and it’s brutal in professional hands, too. It’s simply the nature of this procedure. I’ve found I can stomach the pain easier if I’m in charge of it.
While I was in Korea, I kept telling my injector that I didn’t want anymore and that whatever was placed was enough for me.
I tried to bow out early, but she insisted I needed to keep going 😂🙈.
If you’ve ever seen my Korean Thread Video, you know I was trying to escape!
KOREAN THREAD 🎥
https://urlgeni.us/youtube/PDOThreads
The point I want to offer is that not all at-home beauty treatments are as painful as mesotherapy. The major reason Mesotherapy is painful is that you have large areas of skin to cover. You can use numbing cream to take a bit of the bite off, but even 12% topical lido is not going to fully numb you. Some pokes are easy, and others painful.
Mid-face and lip areas are by far my most sensitive regions, and each time I make it through, I feel like a superhero 🦸♀️😅.
I’m motivated by the convenience of performing these procedures at home. Although I don’t look forward to the pain of mesotherapy, I’m always encouraged by the benefits these products have for my skin.
I love the ability and freedom to choose for myself, and I appreciate it when others feel empowered as well.
I’ve never infered that my life choices are suitable for everyone; only that options exist, and that’s why I share.
My community, found inside the Natural Kaos App, is where these procedures take place.
NATURAL KAOS APP
https://urlgeni.us/AppInstall
How I prepare to do Mesotherapy Injections?
I’m using Mayster PLLA. Today is my second round with this quasi Sculptra dupe. The reason I say “quasi” is because it has a lower molecular weight so the particles are not nearly as large as the PLLA molecules in Sculptra.
I’m using this product inside the Natural Kaos App.
You can find it on Apple and Android
I go Live at 4pm pst but all lives are saved inside the app for your future convenience.
Gain more insight on our app @natural.kaos.app account which showcases more of our weekly lives.
How I prepare to do Mesotherapy Injections?
I’m using Mayster PLLA. Today is my second round with this quasi Sculptra dupe. The reason I say “quasi” is because it has a lower molecular weight so the particles are not nearly as large as the PLLA molecules in Sculptra.
I’m using this product inside the Natural Kaos App.
You can find it on Apple and Android
I go Live at 4pm pst but all lives are saved inside the app for your future convenience.
Gain more insight on our app @natural.kaos.app account which showcases more of our weekly lives.
Last week, I shared a one-year-out Sculptra video, a result of the two sessions I had the privilege of receiving from the esteemed Dr Rice @estheticscenter in 2023.
Comment “Sculptra” for the full video link sent to your DM 📥 + Last minute Mother’s Day gift ideas.
I received a few comments stating:
1️⃣ “Sculptra can’t be placed beneath the eyes!”
2️⃣ “If you get Sculptra, you are no longer a candidate for a future facelift!”
Both of these statements are false, but I understand why some people have this perspective.
1️⃣ Most people go to med spas where RNs inject. RN injectors are fabulous and typically do more liquid facelift protocols than even the surgeon. However, at some locations, you may find they do not offer certain placements, like the tear trough. This is their decision based on comfort level.
I elected to pay more to have Dr Rice place my Sculptra because I knew he was the best person for this situation.
2️⃣ Offices like @estheticscenter, which profit from facelifts, don’t want to create a population of clientele that later would not be candidates for a facelift.
I truly dislike it when people attempt to fearmonger about products and procedures. It’s always better to look at the larger picture.
If Sculptra were to hinder a facial plastic surgeon from performing facelifts, it would never be in the doctor’s best interest to offer Sculptra. Dr Rice, for instance, is dedicated to serving his patients and providing them with a range of options, ensuring their best interests are always prioritized.
I hope this continues the conservation about Sculptra and gives more insight on why you may go to a med spa and they may not offer Sculptra placement under the eyes.
SCULPTRA 🎥 https://urlgeni.us/youtube/Sculptra
Last week, I shared a one-year-out Sculptra video, a result of the two sessions I had the privilege of receiving from the esteemed Dr Rice @estheticscenter in 2023.
Comment “Sculptra” for the full video link sent to your DM 📥 + Last minute Mother’s Day gift ideas.
I received a few comments stating:
1️⃣ “Sculptra can’t be placed beneath the eyes!”
2️⃣ “If you get Sculptra, you are no longer a candidate for a future facelift!”
Both of these statements are false, but I understand why some people have this perspective.
1️⃣ Most people go to med spas where RNs inject. RN injectors are fabulous and typically do more liquid facelift protocols than even the surgeon. However, at some locations, you may find they do not offer certain placements, like the tear trough. This is their decision based on comfort level.
I elected to pay more to have Dr Rice place my Sculptra because I knew he was the best person for this situation.
2️⃣ Offices like @estheticscenter, which profit from facelifts, don’t want to create a population of clientele that later would not be candidates for a facelift.
I truly dislike it when people attempt to fearmonger about products and procedures. It’s always better to look at the larger picture.
If Sculptra were to hinder a facial plastic surgeon from performing facelifts, it would never be in the doctor’s best interest to offer Sculptra. Dr Rice, for instance, is dedicated to serving his patients and providing them with a range of options, ensuring their best interests are always prioritized.
I hope this continues the conservation about Sculptra and gives more insight on why you may go to a med spa and they may not offer Sculptra placement under the eyes.
SCULPTRA 🎥 https://urlgeni.us/youtube/Sculptra
Happy Sunday…
Warm spring finally arrived and soon it will be in the 90’s.
This week also brought me a cold 🤧
It began with Pink Eye and by Friday I lost my voice.
I woke up on Saturday with a deep cough.
I’ve been in bed this weekend trying to recover so next weeks schedule isn’t compromised.
I’m still planing to do my next session of Mayster PLLA on Monday 5/6, inside the natural Kaos app.
Hopefully my voice can recover more so you can actually hear what I’m saying 😂.
If you know me, you know I like to talk 🗣️🎙️and losing my voice is certainly a difficult by product of this seasonal cold.
If you’ve experienced this years cold let me know if thee is another phase to this that I’ve yet to encounter?
For my app members please know I will rally to make Mondays Live demo. In the end if I still lack a voice I’ll have to cancel only because it would be super annoying to listen to me speak.
Stay tuned:)
PS. I filmed this on Thursday before this cold entered my 🫁.
It was also my third day injecting MELANOTAN 2 and laying out to trigger the melanin in my skin.
Happy Sunday…
Warm spring finally arrived and soon it will be in the 90’s.
This week also brought me a cold 🤧
It began with Pink Eye and by Friday I lost my voice.
I woke up on Saturday with a deep cough.
I’ve been in bed this weekend trying to recover so next weeks schedule isn’t compromised.
I’m still planing to do my next session of Mayster PLLA on Monday 5/6, inside the natural Kaos app.
Hopefully my voice can recover more so you can actually hear what I’m saying 😂.
If you know me, you know I like to talk 🗣️🎙️and losing my voice is certainly a difficult by product of this seasonal cold.
If you’ve experienced this years cold let me know if thee is another phase to this that I’ve yet to encounter?
For my app members please know I will rally to make Mondays Live demo. In the end if I still lack a voice I’ll have to cancel only because it would be super annoying to listen to me speak.
Stay tuned:)
PS. I filmed this on Thursday before this cold entered my 🫁.
It was also my third day injecting MELANOTAN 2 and laying out to trigger the melanin in my skin.
Comment “Sculptra” for the video link sent to your DM inbox. On FACEBOOK? Link 👇🏻
Are you sitting on the fence about Sculptra? I know it’s really $$$!!!
If you want to see the impact of four vials of Sculptra 12 months post then you’ll appreciate todays YouTube video.
Premiers at 5:15pm PST on the @spa.and.tell YouTube channel.
🎥 LINK: https://urlgeni.us/youtube/Sculptra
#sculptra #sculptraaesthetic #beforeandafter
Comment “Sculptra” for the video link sent to your DM inbox. On FACEBOOK? Link 👇🏻
Are you sitting on the fence about Sculptra? I know it’s really $$$!!!
If you want to see the impact of four vials of Sculptra 12 months post then you’ll appreciate todays YouTube video.
Premiers at 5:15pm PST on the @spa.and.tell YouTube channel.
🎥 LINK: https://urlgeni.us/youtube/Sculptra
#sculptra #sculptraaesthetic #beforeandafter
SAVE for future and comment “SPRAY” for the one I’m using.
Silver is an ancient remedy and before we had antibiotics the world used silver to fight infections. In fact, the Phoenicians stored water, wine and vinegar in silver bottles to prevent spoiling.
BENEFITS
Used for centuries for its antibacterial properties, it’s a must-have in any home medicine cabinet…because you can be 42 years old and contract PINK EYE!
1. **Antibacterial Powerhouse:** Colloidal silver is renowned for its ability to fight off harmful bacteria. Whether it’s on your skin or in your body, colloidal silver works to eliminate bacteria and promote a healthy environment.
2. **Gentle Yet Effective:** Unlike harsh chemical antibacterials, colloidal silver is gentle on the body while still delivering potent results. It targets bacteria without disturbing the body’s natural balance, making it suitable for daily use.
3. **Versatility:** From skincare to immune support, colloidal silver offers a wide range of benefits. Use it topically to soothe minor skin irritations or internally to bolster your immune system and fend off infections.
4. **Natural Alternative:** Say goodbye to synthetic antibiotics and hello to nature’s solution! Colloidal silver provides a natural alternative to traditional antibacterial treatments, making it a favorite among holistic health enthusiasts.
I’m using the @sovereignsilver hydrosol spray.
#pinkeye
SAVE for future and comment “SPRAY” for the one I’m using.
Silver is an ancient remedy and before we had antibiotics the world used silver to fight infections. In fact, the Phoenicians stored water, wine and vinegar in silver bottles to prevent spoiling.
BENEFITS
Used for centuries for its antibacterial properties, it’s a must-have in any home medicine cabinet…because you can be 42 years old and contract PINK EYE!
1. **Antibacterial Powerhouse:** Colloidal silver is renowned for its ability to fight off harmful bacteria. Whether it’s on your skin or in your body, colloidal silver works to eliminate bacteria and promote a healthy environment.
2. **Gentle Yet Effective:** Unlike harsh chemical antibacterials, colloidal silver is gentle on the body while still delivering potent results. It targets bacteria without disturbing the body’s natural balance, making it suitable for daily use.
3. **Versatility:** From skincare to immune support, colloidal silver offers a wide range of benefits. Use it topically to soothe minor skin irritations or internally to bolster your immune system and fend off infections.
4. **Natural Alternative:** Say goodbye to synthetic antibiotics and hello to nature’s solution! Colloidal silver provides a natural alternative to traditional antibacterial treatments, making it a favorite among holistic health enthusiasts.
I’m using the @sovereignsilver hydrosol spray.
#pinkeye
It’s not easy having your world unexpectedly turned upside down. Challenges happen in life that we are not prepared for no matter if we are planners.
UNFORTUNATELY, Not everything is in our control!
As a “semi-control freak” (don’t judge me) life continues to teach me that I never know what’s around the corner.
And It’s difficult to be prepared for the next curve ball life throws.
As I go thru another tragic experience (one I’m not sharing yet) it can feel debilitating.
Like what the F***!!! I’m NOT equipped for this obstacle.
The only truth I know, is that I can only control myself. I feel fortunate that I developed my little work out plan becoming accustomed to it pre devastation.
My routine is helping me thru this difficult time and I’m grateful to have it as a constant when other aspects of my life feel wild and unknown.
PSA: Get yourself a routine before your next curve ball!
XOXO Kim ❤️🩷🧡❤️🩷🧡❤️🩷🧡❤️🩷🧡❤️🩷
It’s not easy having your world unexpectedly turned upside down. Challenges happen in life that we are not prepared for no matter if we are planners.
UNFORTUNATELY, Not everything is in our control!
As a “semi-control freak” (don’t judge me) life continues to teach me that I never know what’s around the corner.
And It’s difficult to be prepared for the next curve ball life throws.
As I go thru another tragic experience (one I’m not sharing yet) it can feel debilitating.
Like what the F***!!! I’m NOT equipped for this obstacle.
The only truth I know, is that I can only control myself. I feel fortunate that I developed my little work out plan becoming accustomed to it pre devastation.
My routine is helping me thru this difficult time and I’m grateful to have it as a constant when other aspects of my life feel wild and unknown.
PSA: Get yourself a routine before your next curve ball!
XOXO Kim ❤️🩷🧡❤️🩷🧡❤️🩷🧡❤️🩷🧡❤️🩷
Comment “DEAL” for the Nira Link sent to your DM.
SAVE $$$ Code: KIMPRATT
I love the results I see and feel with my Nira Pro.
With a large opening, Nira Pro treats my full face in only 3 minutes a day.
NIRA Pro is the fastest and most powerful at-home laser, FDA-cleared and clinically proven to reduce fine lines and wrinkles.
The Nira Pro blasts heat into your skin, triggering collagen induction that plumps your cheeks and strengthens the skin around your eyes. You can also use it on your neck and even firm your hands.
Developed by laser experts, NIRA Pro is truly one of a kind. Bring the med spa home for visibly firmer, youthful-looking skin in 90 days guaranteed.
After triggering collagen, top with Niras Youth Renewal Peptide cream.
In 60 days, your skin will look five years younger due to its multi-peptide complex, which is clinically proven to increase collagen by 258% for a dramatic wrinkle reduction.
You’ve watched me use my Nira to tighten around my eyes for years because it’s the most powerful at-home device for wrinkle reduction.
Try the Nira Pro and save with code KIMPRATT.
Nira also offers a 90-day money-back guarantee, but there is a reason that Nira has a 4.9 rating…it’s because it works!
FACEBOOK, here is the link: https://bit.ly/4d5vjTX
Save $$$ Code: KIMPRATT
Comment “DEAL” for the Nira Link sent to your DM.
SAVE $$$ Code: KIMPRATT
I love the results I see and feel with my Nira Pro.
With a large opening, Nira Pro treats my full face in only 3 minutes a day.
NIRA Pro is the fastest and most powerful at-home laser, FDA-cleared and clinically proven to reduce fine lines and wrinkles.
The Nira Pro blasts heat into your skin, triggering collagen induction that plumps your cheeks and strengthens the skin around your eyes. You can also use it on your neck and even firm your hands.
Developed by laser experts, NIRA Pro is truly one of a kind. Bring the med spa home for visibly firmer, youthful-looking skin in 90 days guaranteed.
After triggering collagen, top with Niras Youth Renewal Peptide cream.
In 60 days, your skin will look five years younger due to its multi-peptide complex, which is clinically proven to increase collagen by 258% for a dramatic wrinkle reduction.
You’ve watched me use my Nira to tighten around my eyes for years because it’s the most powerful at-home device for wrinkle reduction.
Try the Nira Pro and save with code KIMPRATT.
Nira also offers a 90-day money-back guarantee, but there is a reason that Nira has a 4.9 rating…it’s because it works!
FACEBOOK, here is the link: https://bit.ly/4d5vjTX
Save $$$ Code: KIMPRATT
MOTHERS DAY GIFTS 2024
Maysama LED GIFTS 20% OFF Enjoy an amazing 20% OFF on all LED devices when…
SCULPTRA 1 YEAR AFTER 4 VIALS COMPARISON
https://youtu.be/tMeTSH9umrY?si=PqlaYLIAaq9VVr2O SCULPTRA 1 YEAR AFTER 4 VIALS COMPARISON At $1000 a vial, is Sculptra worth…
Hair Growth with Microneedling at Home
https://youtu.be/IP0lh6UvThA?si=1s167tkPSycILdHJ HAIR REJUVENATION I love long hair and microneedling. You can get hair growth with…
Exosomes, Toxin & Microdosing Tirzepatide
https://youtu.be/JzwAnXfEKm8?si=oUiyDizrHay-W0-v Our App now offers Tirzepatide to App Members. It is prescribed by a US…
TIRZEPATIDE 10mg
Buy Terzepatide NowExclusive for Natural Kaos App Members! We have partnered with Beauty from Korea…
MAYSTER PDRN
https://vimeo.com/938000091?share=copy MAYSTER PDRN Premium Rejuvenator with Brightening EffectsMayster PDRN is a repairing serum that uses…
