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BPC157 + TB500: CAN THIS COMBO HEAL LEAKY GUT?

Walkie Talkie On Monday Feb 26th 2024

BPC157 stands for “BODY PROTECTIVE COMPOUND” BPC157 influences the endothelium and helps it create more mucus.

The use of BPC157 may help with the following: * Ulcerative colitis * Crohn’s Disease * Inflammatory Bowel Disease (IBD) This peptide is stable in gastric juice because it’s made from gastric juice. Other peptides are unstable in gastric juices, which sets BPC157 apart.

What is TB500? There is another name for TB-500, which is Thymosin beta 4 (TB4). After conducting experiments on animal models, it was suggested that Thymosin beta 4 may play a significant part in regulating the structure of cells.

TB500 reduces inflammation and is associated with an improved immune system.

WHAT IS LEAKY GUT? Intestinal permeability, aka “Leaky Gut.”

Leaky gut syndrome is an intestinal condition in which a weakening of the intestinal walls allows bacteria and toxins into the bloodstream. 

Our intestine walls are designed to allow nutrition to pass while preventing bacteria and toxins from entering our bloodstream.

This is the reason why when you hear about “leaky gut,” you also hear the phrase Intestinal Permeability.

Permeability describes the flow of material from one side to another.

GUT LUMEN

Our intestine is a long hose comprised of walls. When you hear “Gut Lumen,” it just means the hole the food is traveling down.

MUCOSA

The innermost wall or lining of the Lumen is called the Mucosa. This is the surface that interacts with everything we put in our mouths.

EPITHELIAL CELL LAYER

This is the surface our food touches and rides against as it descends. The interior lining of our intestine hose comprises a single wall of cells called the Epithelium. This cell layer has little fingers, similar to a silicon scrubbing face brush.

INTESTINAL MUCUS

Besides our epithelial cells allowing nutrition to pass, they also secrete a thick, gel-like mucus that protects our body from irritants.

Our epithelial cells’ first defense against unwanted elements is a robust, thick mucus layer.

Our mucus is an efficient system for protecting the epithelium from bacteria by promoting their clearance, thereby inhibiting inflammation and infection.

Maintaining the balance of bacteria and yeast is critical to keeping this mucus layer thick; thereby, our epithelial cells can stay healthy and secrete more mucus.

WHY IS THE EPITHELIAL LAYER ONLY ONE CELL DEEP?

Our intestinal epithelium is only a single layer of cells. It’s shallow in nature, so nutrition can enter while blocking bacteria.

Our epithelial cells are attached to one another by proteins called junctions. Rather than deep diving into the junctions and their individual functions, simply understand that we want these junctions tight.

When nutrition passes through these junctions between our epithelial cells, it enters our bloodstream.

Without a thick mucus layer, our epithelial cells are left exposed to microbes and toxins we ingest daily.

ZONULIN

Zonulin is a molecule responsible for opening up the gaps between neighboring epithelial cells of the gut lining. Under certain conditions, too much zonulin is produced, causing the tight junctions between the epithelial cells to open up too much, creating a leaky gut condition.

WHY DOES INFLAMMATION OCCUR IN THE GI TRACT?
LAMINA PROPRIA

Lamina propria is a thin layer of connective tissue found just under the surface of Epithelial cells. 

This thin layer of tissue consists of long, thin, supporting cells called fibroblasts. The fibroblasts are surrounded by small blood vessels and a variety of inflammatory cells that protect the body from microbes that may enter the body through the surface tissue, in this case, the epithelial cells.

As irritants enter into the LAMINA PROPRIA layer, inflammation builds as our immune system fights invaders. This inflammation causes epithelial death, widening the already compromised junction.

WE NEED THICK MUCUS

When our gut is void of a thick mucus lining (remember the epithelial cells make this mucus) along with tight junctions between these cells, nutrition is not absorbed correctly, plus bacteria and toxins have a wider path of entry.

The Leaky Gut concept is basically that our intestinal wall is weak, and toxins that would normally be dispelled are now entering our blood.

WHAT DESTROYS MUCUS?

What are Leaky Gut Symptoms?

WHY DO I THINK I HAVE “LEAKY GUT”?
  1. My entire life, I’ve never had regular bowel movements. I’m completely acclimated to this condition. In fact, even while on Semaglutide (the GLP-1 peptide that helps satiate but slows down digestion), the slow bowel movement was normal for me.
  2. In my twenties, I was diagnosed with Ulcerative Colitis, which is an autoimmune disorder. I took steroids, and my symptoms resolved. 
  3. I’ve always had a hard time keeping weight off no matter what I did.
  4. I do suffer from unstable moods, and I’ve used psych meds in the past to help during severe moments in life.
  5. In January 2024, I was diagnosed with Hashimoto’s Disease, which is an autoimmune disorder that destroys the thyroid.

The development of autoimmune disorders has been linked to the GI Tract because of the immune response that is displayed in the Lumina Propria layer. As the inflammation in the GI tract persists, it leads to systemic issues all over the body. This is because of the Gut-Brain Axis.

GUT-BRAIN AXIS

The gut-brain axis (GBA) consists of bidirectional communication between the central and the enteric nervous system, linking emotional and cognitive centers of the brain with peripheral intestinal functions. Recent advances in research have described the importance of gut microbiota in influencing these interactions.

Besides many of the physical symptoms of leaky gut, I also have Anxiety, Insomnia, Fatigue, and Brain Fog. I imagine if I don’t quickly solve these symptoms, I will eventually develop more severe neuro-degenerative issues.

We can destroy our intestinal biome with diet, stress, and antibiotics, but some of us are more susceptible to this condition than others. I believe I must have genetic contributors as my mom, her mom, and my great-grandma all had bathroom issues and, consequently, mood disorders. As I’ve researched, I believe this is all linked, and I believe that by healing my intestinal wall, I will be able to heal my mind along with the other physical improvements.

TESTING GI TRACT

<br>

Until I have my GI Intelligence test results, I’m restricting gluten, which is known to be inflammatory, and I’m adding in probiotics like Kefir and kimchi.

Remember Zonulin? The Zonulin molecule opens tight junctions, allowing nutrition inside. Zonulin can be tested for and tracked. Gluten increases levels of Zonulin, which is why people who have celiac disease avoid gluten.

Now you understand what Leaky Gut is, why it occurs, and how it can damage many systems in your body.

PEPTIDE’S I’M USING

Besides diet changes, I decided to use BPC157 with TB500 to amplify the healing of my gut mucosal layer.

What is BPC157?

BPC, a.k .a. Body Protective Compound, is synthesized from gastric juices. It was discovered in the early 1990s.

Researchers found that BPC157 has a positive impact on many gastrointestinal issues, along with a reduction in oxidative stress and improved blood vessels.

BPC157 influences the endothelium and helps it create more mucus.

The use of BPC157 may help with the following:

  • Ulcerative colitis
  • Crohn’s Disease
  • Inflammatory Bowel Disease (IBD)

This peptide is stable in gastric juice because it’s made from gastric juice.

Other peptides are unstable in gastric juices, which sets BPC157 apart.

What is TB500?

There is another name for TB-500, which is Thymosin beta 4 (TB4). 

TB4 is found in every cell in the body. It is found in higher amounts at injury sites as it promotes healing.

TB4 is not identical to TB500.  TB4 is made up of 43 amino acids.

TB500 has 7 amino acids, it’s considered a fragment.

As peptide research continues, scientists have identified what amino acids in the sequence actually bind to the anti-inflammatory receptor, they isolate that sequence and create a new peptide, in this case TB500 is a fragment chain from T4 that is focused on inflammation reduction.

TB4 (43 amino acid chain) has wider effects than TB500. However, because of this isolation TB500 is better at reducing inflammation.

After conducting experiments on animal models, it was suggested that Thymosin beta 4 may play a significant part in regulating the structure of cells.

TB4 works by binding to actin for cell mobility. It is responsible for building the matrix or cytoskeleton that we need for cell growth.

Stem cells need to TB4 because they require a scaffold structure to grow and require the information TB4 signals so that the Stem Cell knows where to go and what type of cell to become.

This is the reason TB4 is the first activated protein when it comes to cellular growth and telling stem cells what is needed.

.

.

TB4 works by binding to actin for cell mobility. It is responsible for building the matrix or cytoskeleton that we need for cell growth.

Stem cells need to TB4 because they require a scaffold structure to grow and require the information TB4 signals so that the Stem Cell knows where to go and what type of cell to become.

This is the reason TB4 is the first activated protein when it comes to cellular growth and telling stem cells what is needed.

How TB4 works in the body.

TB4 generates ATP using a hydrogen gradient, this opens the P2X4 port which signals cell migration.

Why are BPC157 & TB4 combined?

Researchers have shown that these 2 peptides can manage weight loss, promote muscle growth, and deliver anti-aging benefits.

It’s found that improving blood vessels is necessary to deliver immune function to cells along with the site of the injury or infection.

The ability of the peptides to spread blood vessels, which are passageways for these critical aids, helps explain why they are excellent at tissue repair.

BPC157 interacts with the body’s vascular endothelial growth factor (VEGF) receptors.

Meanwhile, TB500 directly increases the production of VEGF, which is why it’s essential to pair the two peptides together.

I’ve been injecting BPC157 with TB500, as a combo, you can understand how effective they are at injury repair. This is why these peptides can be injected at the injury site to improve vessel growth and reduce inflammation.

After research, I believe taking BPC157 with gut healing in mind is actually more effective as an oral supplement. This is because when taken orally, BPC157 can survive the gastric acids of the stomach and be directly absorbed in the small intestine, hopefully impacting the epithelial cell layer quicker.

The injection is still beneficial, especially for injury-specific applications. However, not everyone wants to inject. In particular, taking an oral dose when healing the gut appears to perhaps be more effective.

I will continue my cycle with BPC157 and TB500; however, I will use BPC157 orally as well to see if I can improve my mucosal lining more quickly.

Further, if you are injecting BPC157 + TB500 with healing your gut as the primary focus, you don’t need to stagger the dose with two injections. You can do one injection per day with your total dose rather than breaking them up AM and PM.

For specific injury injection it’s found to be more effective to break this dose up AM and PM.

Again, these peptides are incredible at effective healing. But your purpose plays a huge part in how you use them.

BPC157 ORAL & INJECTION DOSING

LINK: BPC157 ORAL SUPPLEMENT 500mg

LINKED SOURCES

LEAKY GUT

NITRIC OXIDE 

PEPTIDES EXPLAINED

PODCAST ON GUT

INTESTINAL TRACT 

ARTICLE 1

ARTICLE 2

Thank you for joining me today and I hope you join me for more live content! We do have a Peptide group in The Natural Kaos App ! xo – Kim

NATURAL KAOS APP LINKS

LINK: PEPTIDE STACKING 

NATURAL KAOS APP COMMUNITY


TIRZEPATIDE DEAL explained 👇🏻
“Walkie-Talkie” realities of peptides and personal goals:)

DAY 8 of 3 Mile/Day Walk Challenge
 
In todays, little LIVE Walk, which took 4 hrs to finally post 🤯🙈 ugh tech!

I explained about my 3 mile per day walk goal and how the time commitment for this goal is harder than I anticipated…but we are going to continue…

✅ I walk at a 5 incline at between a 3 & 3.5 mph pace. 
I use a @nordictrack 

I shared about the peptides I started this week. Tirzepatide and MELANOTAN 2 and my thoughts/plans with these two peptides.

We touched on skin concepts such as PLLA, PCL, TOX, & MESO.

This past Monday I injected 5ml of Mayster PDRN from my temples, to my cheeks, to above my lip. That LIVE demo is found inside the Natural Kaos App. 

🎁TIRZEPATIDE DEAL!!! 
We are so lucky to finally find a source and a MD who will work with the Natural Kaos App and provide our members with this amazing peptide at the best cost possible!

10MG Vial of Tirzepatide, For $160
It ships from a California doctors office anywhere in the US and worldwide.
✅ ONLY For active Natural Kaos APP Members

To learn more about this real I have a blog up on the Naturalkaos.com blog explaining more. 

If you aren’t already a Natural Kaos APP member now is the time so you can be Bikini 👙 Ready for Summer 2024!!!

We are currently working on deals for additional peptides as well…standby

TIRZEPATIDE DEAL explained 👇🏻
“Walkie-Talkie” realities of peptides and personal goals:)

DAY 8 of 3 Mile/Day Walk Challenge

In todays, little LIVE Walk, which took 4 hrs to finally post 🤯🙈 ugh tech!

I explained about my 3 mile per day walk goal and how the time commitment for this goal is harder than I anticipated…but we are going to continue…

✅ I walk at a 5 incline at between a 3 & 3.5 mph pace.
I use a @nordictrack

I shared about the peptides I started this week. Tirzepatide and MELANOTAN 2 and my thoughts/plans with these two peptides.

We touched on skin concepts such as PLLA, PCL, TOX, & MESO.

This past Monday I injected 5ml of Mayster PDRN from my temples, to my cheeks, to above my lip. That LIVE demo is found inside the Natural Kaos App.

🎁TIRZEPATIDE DEAL!!!
We are so lucky to finally find a source and a MD who will work with the Natural Kaos App and provide our members with this amazing peptide at the best cost possible!

10MG Vial of Tirzepatide, For $160
It ships from a California doctors office anywhere in the US and worldwide.
✅ ONLY For active Natural Kaos APP Members

To learn more about this real I have a blog up on the Naturalkaos.com blog explaining more.

If you aren’t already a Natural Kaos APP member now is the time so you can be Bikini 👙 Ready for Summer 2024!!!

We are currently working on deals for additional peptides as well…standby

25 2
Where to BUY Tirzepatide??? Comment “DEAL”

This has been a question I’ve fielded all 2024. 

I’m happy to share that we have secured a special deal for our Natural Kaos App members.

$160 for 10mg of Tirzepatide issued by an MD.
Shipped from California to all US + Worldwide.

This deal is available to our Natural Kaos App members.
Our app is found on both Apple and Android.

Comment “DEAL” in the comments and I’ll send you the link to our app and to the Tirzepatide Blog about this deal.

Everyone is going to bikini ready this summer with this deal!!!

#weightlosstransformation

Where to BUY Tirzepatide??? Comment “DEAL”

This has been a question I’ve fielded all 2024.

I’m happy to share that we have secured a special deal for our Natural Kaos App members.

$160 for 10mg of Tirzepatide issued by an MD.
Shipped from California to all US + Worldwide.

This deal is available to our Natural Kaos App members.
Our app is found on both Apple and Android.

Comment “DEAL” in the comments and I’ll send you the link to our app and to the Tirzepatide Blog about this deal.

Everyone is going to bikini ready this summer with this deal!!!

#weightlosstransformation

254 223
MESO MONDAY:)

Today inside the Natural Kaos App I will be reconstituting two Peptides: 
-Melanitan 2
-Tirzepatide (not for weightloss, I’m microdosing)

Next…
I will mix up the Mayster PDRN and place it in my face.

PDRN BENEFITS:
PDRN molecules are able to stimulate the metabolic activity of cells in your skin to regenerate collagen. 

It can also stimulate wound recovery through boosting the rate of growth of fibroblasts, the cells mainly responsible for collagen production.

The activator in this set has glutathione which will brighten my skin as new tissue is encouraged to grow.

SCHEDULE:
-3PM PST TIKTOK LIVE PREP (numb up)
-4PM PST APP LIVE (application)

MESO MONDAY:)

Today inside the Natural Kaos App I will be reconstituting two Peptides:
-Melanitan 2
-Tirzepatide (not for weightloss, I’m microdosing)

Next…
I will mix up the Mayster PDRN and place it in my face.

PDRN BENEFITS:
PDRN molecules are able to stimulate the metabolic activity of cells in your skin to regenerate collagen.

It can also stimulate wound recovery through boosting the rate of growth of fibroblasts, the cells mainly responsible for collagen production.

The activator in this set has glutathione which will brighten my skin as new tissue is encouraged to grow.

SCHEDULE:
-3PM PST TIKTOK LIVE PREP (numb up)
-4PM PST APP LIVE (application)

275 52
Monday “Katch Up” Walkie-Talkie

TODAY:
-3pm PST TIKTOK Prep
-4pm PST App LIVE (PDRN in Face + Melanatan 2 & Tirzepatide)

Find the APP linked in my profile or search “Natural Kaos” or Apple or Android.

Gain additional insight by following our app account, @natural.kaos.app 

NEW YouTube @spa.and.tell 

Life has become even busier due to this random goal I set for myself…

If I had contemplated this goal more I probably wouldn’t have started or shared it.

30 DAY GOALS:

-Walking 3 miles everyday takes me an hour.

-I alternate Hot Yoga and Weight Training each day, each of these activities takes me an hour or more.

-My Core challenge takes me 30-60 minutes as I learn how to do the exercises.

This scenario takes me 3 hours to complete daily. That’s a huge chunk of time and is causing me stress as I attempt to fit it all in…and yes I get tired too 🤣

I just keep telling myself it’s only 30 days you can do it.

The trick to this challenge is time management and I think that’s the insight I will glean from this next month.

Because of time restraints and a brand project I have this week…we are going to repurpose a video from the previous YouTube channel. I think it will be the microneedling scalp video.

Monday “Katch Up” Walkie-Talkie

TODAY:
-3pm PST TIKTOK Prep
-4pm PST App LIVE (PDRN in Face + Melanatan 2 & Tirzepatide)

Find the APP linked in my profile or search “Natural Kaos” or Apple or Android.

Gain additional insight by following our app account, @natural.kaos.app

NEW YouTube @spa.and.tell

Life has become even busier due to this random goal I set for myself…

If I had contemplated this goal more I probably wouldn’t have started or shared it.

30 DAY GOALS:

-Walking 3 miles everyday takes me an hour.

-I alternate Hot Yoga and Weight Training each day, each of these activities takes me an hour or more.

-My Core challenge takes me 30-60 minutes as I learn how to do the exercises.

This scenario takes me 3 hours to complete daily. That’s a huge chunk of time and is causing me stress as I attempt to fit it all in…and yes I get tired too 🤣

I just keep telling myself it’s only 30 days you can do it.

The trick to this challenge is time management and I think that’s the insight I will glean from this next month.

Because of time restraints and a brand project I have this week…we are going to repurpose a video from the previous YouTube channel. I think it will be the microneedling scalp video.

75 26
Just for laughs… it’s amazing to me what Ai auto captions will pull especially from the gym 😂
The music and the side conversations are combined into an interesting story…
Happy Friday

Just for laughs… it’s amazing to me what Ai auto captions will pull especially from the gym 😂
The music and the side conversations are combined into an interesting story…
Happy Friday

50 16
My 3 mile walking goal!

If you watched last nights YouTube video on lymphatic drainage you heard me explain my 30 day, 3 mile walking goal.

This was my third day in a row. I’m already scared 🙈 but I’m just going to take it day by day and fit it in where I can.

Tonight Tyler @tyler89libra will be doing a MESO LIVE in the app. 

Then Rhonda @pancakequeen57 will be using threads LIVE in the app on Sunday in the app.

This weekend @fillerhouse_ is having a 41% off sale.

Monday I plan to use Mayster PDRN LIVE in the app.

Next Thursday will be my full Sculptra experience video.

My 3 mile walking goal!

If you watched last nights YouTube video on lymphatic drainage you heard me explain my 30 day, 3 mile walking goal.

This was my third day in a row. I’m already scared 🙈 but I’m just going to take it day by day and fit it in where I can.

Tonight Tyler @tyler89libra will be doing a MESO LIVE in the app.

Then Rhonda @pancakequeen57 will be using threads LIVE in the app on Sunday in the app.

This weekend @fillerhouse_ is having a 41% off sale.

Monday I plan to use Mayster PDRN LIVE in the app.

Next Thursday will be my full Sculptra experience video.

87 18
Comment “MASSAGE” for this YouTube video link.

🎥Can Lymphatic Drainage Massage Tone Your Abs And Decrease Inflammation?

Premiers tonight 4/18/24 at 5:15pm PST (8:15pm EST)

Those on FACEBOOK 
https://urlgeni.us/youtube/LymphaticDrainageMassage

 ✅What are the benefits of Lymphatic Massage?

Our lymphatic system is key to our body’s immune defenses. 

Lymphatic fluid flows through lymph vessels, which connect lymph nodes. White blood cells trap and destroy harmful particles, such as bacteria, as lymph fluid passes through lymph nodes.

Similar to blood in the circulatory system, lymphatic fluid is always moving. If it stops, fluid build-up can cause swelling, often in the arms or legs. 

Exercise is crucial to avoid lymph fluid build-up, which is why walking is essential following surgery.

Combine walking with lymphatic drainage to encourage further movement and clearing of fluid.

If you are not post-surgery but feel inflamed, schedule a lymphatic drainage massage and start walking. It’s amazing what walking and light touch can do and how much better you will feel.

#abs #sculpted

Comment “MASSAGE” for this YouTube video link.

🎥Can Lymphatic Drainage Massage Tone Your Abs And Decrease Inflammation?

Premiers tonight 4/18/24 at 5:15pm PST (8:15pm EST)

Those on FACEBOOK
https://urlgeni.us/youtube/LymphaticDrainageMassage

✅What are the benefits of Lymphatic Massage?

Our lymphatic system is key to our body’s immune defenses.

Lymphatic fluid flows through lymph vessels, which connect lymph nodes. White blood cells trap and destroy harmful particles, such as bacteria, as lymph fluid passes through lymph nodes.

Similar to blood in the circulatory system, lymphatic fluid is always moving. If it stops, fluid build-up can cause swelling, often in the arms or legs.

Exercise is crucial to avoid lymph fluid build-up, which is why walking is essential following surgery.

Combine walking with lymphatic drainage to encourage further movement and clearing of fluid.

If you are not post-surgery but feel inflamed, schedule a lymphatic drainage massage and start walking. It’s amazing what walking and light touch can do and how much better you will feel.

#abs #sculpted

46 18
WEIGHT CHECK ✅

It’s been a while since I shared my weight. 

In January my weight dropped to 103 lbs and I didn’t feel well.

A couple months later I feel tremendously better. It’s been a mix of Testosterone, Thyroid, Peptides, lowering my stress, making new friends, leaving my house, and lifting weights again.

During March I was not very disciplined. And I’ve had a hard time getting back into my routine. 

Because I wasn’t focused in March I didn’t weigh myself. I also didn’t want my mind getting crazy if I saw the scale increasing. I know I wanted it to go up…but still it’s a mental thing 🙈

Today I got back on the scale. 
I’m 116 lbs and 22% fat. I feel much healthier right now than I did in January. 

GYM TODAY:

CHEST
-Upright Chest Press, 5 sets, 12-15 reps
-Cable Flies, 4 sets, 12-15 reps

BICEPS
-Hammer curls, 5 sets, 12-15 reps
-Extended cable bicep curls, 4 sets, 12-15 reps

CORE
-TRX reverse ab crunches 2 sets, 20 reps

It was quick. I also walked 3 miles this morning.

#weightlossjourney #bodytransformation #over40

WEIGHT CHECK ✅

It’s been a while since I shared my weight.

In January my weight dropped to 103 lbs and I didn’t feel well.

A couple months later I feel tremendously better. It’s been a mix of Testosterone, Thyroid, Peptides, lowering my stress, making new friends, leaving my house, and lifting weights again.

During March I was not very disciplined. And I’ve had a hard time getting back into my routine.

Because I wasn’t focused in March I didn’t weigh myself. I also didn’t want my mind getting crazy if I saw the scale increasing. I know I wanted it to go up…but still it’s a mental thing 🙈

Today I got back on the scale.
I’m 116 lbs and 22% fat. I feel much healthier right now than I did in January.

GYM TODAY:

CHEST
-Upright Chest Press, 5 sets, 12-15 reps
-Cable Flies, 4 sets, 12-15 reps

BICEPS
-Hammer curls, 5 sets, 12-15 reps
-Extended cable bicep curls, 4 sets, 12-15 reps

CORE
-TRX reverse ab crunches 2 sets, 20 reps

It was quick. I also walked 3 miles this morning.

#weightlossjourney #bodytransformation #over40

160 45

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